We know what you're thinking: Cleveland got off the schneid last season in Game 15 by beating the Chargers for the Browns' only win.
For that to happen again would be a huge upset considering how LA has gone from 0-4 to contention in the AFC West.
The Browns are 1-26 in two seasons under coach Hue Jackson and 4-44 in the past 48 games — the worst stretch in NFL history.
"They're really good," said Chargers' tight end Hunter Henry about the winless Browns. "Everyone knows about their record and knows what people say on the outside world, but they're in every single game and fighting to the finish and you would never really know that's what their record is. They have a really good defense."
The Chargers could go sack-happy with Joey Bosa and Melvin Ingram.
Fantasy Football Start/Sit:
Start: Phillip Rivers, Melvin Gordon, Isaiah Crowell, Austin Ekeler (Flex only), Keenan Allen, Hunter Henry, Chargers Defense.
Sit: DeShone Kizer, Duke Johnson, Corey Coleman, Josh Gordon, Tyrell Williams, Mike Williams, Antonio Gates, David Njoku, Travis Coons, Zane Gonzalez, Browns Defense.
Betting Odds (Courtesy of Bovada):
Browns: +13.5 (-115)
Chargers: -13.5 (-125)
Prediction: 28-14 Chargers
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The Associated Press contributed to this story.