A woman was killed early Wednesday when her car collided with a big rig on the eastbound 210 freeway in Irwindale. She was thrown out of her sedan when it hit a guard rail.
The crash was reported about 3 a.m. Wednesday, just west of Irwindale Avenue.
Three other people involved in the crash were taken to the hospital.
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Four eastbound lanes of the 210 Freeway were blocked, causing a major traffic back-up in the area. The road was reopened at about 7 a.m.