The Brussels airport reopened with an "emotional" flight on Sunday, 12 days after suicide bombers destroyed its departure hall, NBC News reported.
Belgium's main airport had not handled passenger flights since the twin bombings killed dozens and injured 270 others.
The first of three scheduled flights departed for Faro in Portugal just after 1:40 p.m. local time (7:40 a.m. ET), with only about 60-70 passengers. Planes were also scheduled to go to Turin and Athens.
On Monday, the airport will serve a far wider range of destinations, including one plane also due out to New York and two more to cities in Cameroon, Gambia and Senegal.