This was no laughing matter.
Chelsey Handler had knee surgery on Thursday, Us Weekly reported.
The funnywoman missed the night’s taping of her late-night series “Chelsea Lately, but she assured her fans via Twittter that she was doing just fine.
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"Fortune Feimster will be filling in as the host on tonight's show with more photos of me and my knee making a quick recovery. Pls support her," the comic wrote on her Twitter page.
Handler also posted a snapshot of herself in a hospital bed munching on graham crackers, according to Us.
The stand-up comedian and actress delivered a pre-taped message on her Thursday broadcast, where Feimster interviewed “Real Housewives of Orange County's” Gretchen Rossi and Tamra Barney.
"I just woke up from surgery -- from my vaginal rejuvenation surgery," Handler joked about her hospital stay.
Handler did not explain why she needed the knee operation.