At least 45 people were killed and 110 wounded on Sunday from a triple explosion in the Sayeda Zeinab district of Damascus where Syria's holiest Shi'ite shrine is located, the interior ministry said.
Syrian state television SANA said a group of militants detonated a car bomb at a bus station, followed by two blasts set off by suicide bombers as rescuers rushed to the scene of the first explosion.
Syrian Prime Minister Wael al-Halaki was quoted as saying the attacks were prompted by "terror groups" who sought to "raise their morale after a string of defeats" by the army.
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The blasts came as a U.N. envoy attempted to launch indirect peace talks between delegations sent to Geneva by the Syrian government and the opposition.