2021 Thursday Night Football Schedule originally appeared on NBC Sports Washington
The final Thursday Night Football game of the 2021 NFL season is set to take place in Music City this week.
The San Francisco 49ers travel east to take on the Tennessee Titans to kick off Week 16 in the NFL. The 8-6 49ers sit in the second NFC wild card spot, while the 9-5 Titans lead the AFC South by one game. These two squads only play once every four years, so the unfamiliarity between the teams will create an interesting primetime matchup.
San Francisco is trending in the right direction after a bumpy beginning to the season. Since starting 2-4, the 49ers have won six of their last eight games. Led by Jimmy Garoppolo and George Kittle, the offense has quietly come to life. They've surpassed 25 points in five of the last six games.
While the 49ers are ascending, the Titans have been descending. Tennessee has dropped three of its last four games, including loss to current non-playoff teams in the Houston Texans and Pittsburgh Steelers. The team has badly missed star running back Derrick Henry, who likely won't return until the postseason.
Here's the TNF schedule for the final game of the season:
Thursday Night Football Schedule 2021
Dec. 23: San Francisco 49ers at Tennessee Titans
Time: 8:20 p.m. ET
Channel: NFL Network