Interstate 10 was closed in both directions, about midway between Indio and Blythe, as law enforcement officers dealt with the end of a pursuit on Sunday.
The closure was publicly broadcast at 10:39 a.m., and blamed only on "police activity." A dispatcher told City News Service it was prompted by the end of a police pursuit.
But no details were available.
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Both eastbound and westbound traffic lanes were blocked near the Eagle Mountain Road interchange, at Desert Center.
The CHP dispatcher said a Sigalert had been issued, and the closure would last for an undisclosed amount of time.