Yu Darvish combined with two relievers on a four-hitter, Manny Machado and Brandon Drury hit two-run homers in the third inning, and the San Diego Padres routed the Los Angeles Dodgers 7-1 on Friday night.
Jurickson Profar added a three-run blast with two outs in the sixth off reliever Heath Hembree in the second-place Padres' fourth straight victory.
Coming off losing two of three at the New York Mets, the NL West leaders returned home and dropped their third in a row for the first time since mid-June. The high-scoring Dodgers managed just six baserunners through eight innings; three times it was Chris Taylor, who got on via two walks and a hit by pitch. He walked again in the ninth.
Five players and the crew chief were hit by pitches.
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Darvish (12-7) struck out nine to reach 3,003 in his professional career. He had 1,250 in Japan's Nippon Professional Baseball and has 1,753 in Major League Baseball since coming to the U.S. in 2012. The right-hander walked two in seven innings.
Steven Wilson struck out one in a 1-2-3 eighth. Nabil Crismatt gave up a double to Justin Turner, who scored on Joey Gallo's single in the ninth.
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Dustin May (1-2) got cuffed around in his third start of the season after returning from Tommy John surgery. The right-hander gave up six runs and four hits in five innings. He struck out five and walked five.
May served up his first homer of the season to Machado, who blasted a 410-foot shot to the left-field pavilion for his 25th homer, scoring Juan Soto who walked, for a 2-0 lead.
Two batters later, Drury went deep to nearly the same spot for his 25th homer, scoring Jake Cronenworth, who was hit by May, and making it 4-0.
The Dodgers' second-best hitter, All-Star Trea Turner, rested for the first time this season.
Dodgers: RHP Tony Gonsolin (right forearm strain) had an MRI and the result was “as good as we could have hoped,” manager Dave Roberts said. The 16-game winner played catch. ... RHP Brusdar Graterol (right elbow inflammation) had an MRI although Roberts didn't yet know the results. ... 2B Gavin Lux has been playing through a neck issue but Roberts said it was “cranky” and he is out of the lineup through Saturday.
Padres: RHP Sean Manaea (7-7, 4.90 ERA) has alternated wins and losses in his last eight starts. He hasn't won two in a row since before the All-Star break.
Dodgers: LHP Julio Urías (14-7, 2.32) has struck out seven in each of his last two starts.