The crash on the eastbound Pomona Freeway just east of Grand Avenue was reported about 3:30 a.m., according to the California Highway Patrol.
The injured were transported for hospital treatment, said CHP Officer David Porter. A woman was pronounced dead, said Sgt. Robert Headden of the CHP's Santa Fe Springs office. The circumstances of the collision were under investigation.
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Several eastbound lanes were closed while crews worked to clear the scene. All lanes were reopened by 6:20 a.m., Porter said.